Heparin-induced thrombosis without thrombocytopenia

Heparin induced thrombocytopenia

Abstract Background and Objectives Heparin is still a commonly used anticoagulant in prophylaxis and treatment of thromboembolic events. Heparin-induced thrombocytopenia (HIT) is a life-threating adverse drug reaction of heparin. The diagnosis of HIT is made based on two important criteria, firstly clinical evaluation and secondly laboratory testing. In this comprehensive review, the authors w...

Plasmapheresis in heparin-induced thrombocytopenia and thrombosis.

To the Editor: Thrombosis associated with severe thrombocytopenia is an infrequent, but life-threatening side effect of heparin therapy, which can involve any venous or arterial territory including the cerebral circulation. The treatment of this serious complication has not been satisfactorily resolved. Recently, Becker and Miller reviewed heparin-induced thrombocytopenia with thromboembolism a...

Heparin-induced thrombocytopenia without thrombocytopenia in an intensive care unit.

[1] Lorette G, Jolly D, Ambrosi P, Dreyfuss D, Magne JL, Kohler C et al. Influence de la lecture critique d’articles sur les classements des étudiants aux épreuves classantes nationales 2009. Presse Med 2010;39(6):e118-25. [2] Giraudeau B, Maruani A. Correspondance à propos de l’article : Heparin-induced thrombocytopenia without thrombocytopenia in an intensive care unit « Influence de la lectu...

Antibodies From Patients With Heparin-Induced Thrombocytopenia/Thrombosis

Antibodies associated with heparin-induced thrombocytopenia/thrombosis (HITT) are now thought to be specific for complexes formed between heparin and platelet factor 4 (PF4), a basic protein found normally in platelet alpha granules. How these antibodies cause thrombocytopenia and, in some patients, thrombosis, is not fully understood, in part because purified antibodies that could be labeled a...

How I treat heparin-induced thrombocytopenia and thrombosis.